So far I've contemplated doing a science information series where I take a complex topic and strip it to the bare essentials and introduce that topic to a general audience. This is making the assumption that people out there are actually interested in complex scientific topics. I could probably obsess over what a recombination hotspot is, but I'm not sure many others would find them that fascinating.
Another idea that would be hard to go wrong with would be a 'how-to' series. I'd introduce one of the many things that I consider to have as a hobby, and basically instruct you how to do something. Examples might include: "How to pull a near-perfect shot of espresso" or "How to tie a basic fishing fly". This would have the advantage of being picture heavy and would probably be more fun for my limited pool of readers.
Hopefully I can begin to incorporate both of these ideas in future posts. I'll start collecting pictures for an instructable today. Stay tuned!